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Brand Name(s): Benadryl; Caladryl; Diphedryl;

Diphen; Diphenhist
CAS nš: 58-73-1
(dye fen HYE dra meen)

What is Diphenhydramine?

Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever and the common cold. These symptoms include rash, itchy and watery eyes, itchy nose/throat, cough, runny nose and sneezing.

This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose and its drowsiness effects are caused by blocking another natural substance made by your body (acetylcholine).


It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Diphenhydramine can also be used to help you relax and fall asleep.

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